NCT06968715

Hydrogen-Rich Water and Metabolic Health in Adults: A 12-Week Randomized Trial

The Effects of 12-week Hydrogen-rich Water Consumption on Body Composition and Metabolic Biomarkers in Adults With Metabolic Syndrome and Varying Breath Hydrogen Levels

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (actual)
• Sponsor: University of Novi Sad, Faculty of Sport and Physical Education · Academic / Other
• Sex: All
• Age: 30 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

The HYDRO-RESPOND trial is a 12-week randomized controlled study investigating the effects of daily hydrogen-rich water (HRW) consumption on body composition and metabolic biomarkers in adults diagnosed with metabolic syndrome. The study also explores whether individual differences in baseline breath hydrogen levels influence response to HRW. Participants are randomly assigned to receive either HRW or a placebo, with outcomes including changes in body fat, waist circumference, glucose metabolism, lipid profiles, and inflammatory markers. The trial aims to determine the therapeutic potential of HRW and identify predictors of individual responsiveness.

Conditions

• Metabolic Syndrome

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Experimental 1: low-breath hydrogen	Hydrogen-rich water (1.0 L/day)
DIETARY_SUPPLEMENT	Experimental 2: high-breath hydrogen	Hydrogen-rich water (1.0 L/day)
DIETARY_SUPPLEMENT	Experimental 3: low-breath hydrogen	Placebo water (1.0 L/day)
DIETARY_SUPPLEMENT	Experimental 4: high-breath hydrogen	Placebo water (1.0 L/day)

Timeline

• Start date: 2025-04-01
• Primary completion: 2025-10-30
• Completion: 2025-11-30
• First posted: 2025-05-13
• Last updated: 2025-12-22

Locations

1 site across 1 country: Serbia