NCT06967051

The Efficacy of a Smart Phone-based Test on Measuring Pupillary Light Reflex Alterations Following Cannabis Use Healthy in Adults

An Open Label Pilot Study Evaluating the Efficacy of a Smart Phone-based Test on Measuring Pupillary Light Reflex Alterations Following Cannabis Use Healthy in Adults

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (estimated)
• Sponsor: Sobereye Inc. · Industry
• Sex: All
• Age: 21 Years
• Healthy volunteers: Accepted

Summary

The goal of this open label study is to evaluate the efficacy of smart phone-based test (SOBEREYE OPTOVERA) on measuring pupillary light reflex (PLR) alterations following cannabis use healthy in adults. The main question it aims to answer is: Can SOBEREYE OPTOVERA detect PLR alterations following cannabis consumption in healthy adults, in comparison to a pupillometer? Participants will be given two 5 mg capsules to be ingested for the 10 mg THC dose or five 5 mg capsules to be ingested for the 25 mg THC. Participants will be asked to complete PLR tests throughout the study day.

Conditions

• Cannabis Intoxication
• Drug Effects

Interventions

Type	Name	Description
DRUG	Tetrahydrocannabinol (10 mg)	10 mg of Tetrahydrocannabinol (THC) provided as a softgel capsule
DRUG	Tetrahydrocannabinol (25 mg)	25 mg of THC provided as a softgel capsule.
DIAGNOSTIC_TEST	Pupillary Light Reflex (PLR) Test	SOBEREYE OPTOVERA is a portable, non-invasive test that measures the Pupillary Light Reflex (PLR)
DIAGNOSTIC_TEST	Pupillometer	NeuroLight is an automated pupillometer that generates a flash of light and measures the photomotor reflex very accurately.

Timeline

• Start date: 2025-05-22
• Primary completion: 2025-08-01
• Completion: 2025-08-01
• First posted: 2025-05-13
• Last updated: 2025-07-17

Locations

1 site across 1 country: Canada