NCT06966206

Multiprofen-CC to Reduce Pain in Hand Arthritis

Multiprofen-CC to Reduce Pain in Hand Arthritis (MRP-HAND): A Crossover Randomized Controlled Trial

• Status: Not Yet Recruiting
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 42 (estimated)
• Sponsor: McMaster University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This clinical trial aims to find out if using 1 gram of Multiprofen-CC cream on the hands three times a day for 4 weeks can help reduce pain in adults with hand osteoarthritis, compared to a placebo (a cream with no active medicine). The research team will also look at how Multiprofen-CC affects hand function, opioid use, and how patients feel about their overall improvement. In addition, the research team will keep track of any side effects. Participants will: * Use both Multiprofen-CC and a placebo (a cream with no active medicine) during the study, in a random order. * Be asked to apply 1 gram of cream to their hands three times a day for 2 weeks, following the manufacturer's instructions. * Attend a visit before starting the study, after 2 weeks, and after 6 weeks. * Report any symptoms they experience during the study.

Conditions

• Hand Osteoarthritis

Interventions

Type	Name	Description
DRUG	Multiprofen-CC™ plus standard treatment	Standard care pain medications and topical Multiprofen-CC™ (1g TID) for 2 weeks
OTHER	Placebo plus standard treatment	Standard care pain medications and visually identical topical placebo (1g TID) for 2 weeks

Timeline

• Start date: 2026-01-01
• Primary completion: 2026-12-31
• Completion: 2027-08-01
• First posted: 2025-05-11
• Last updated: 2026-01-07

Locations

1 site across 1 country: Canada