NCT06964529

Evaluation of the Effects of I-PRF and C-PRF on Gingival Phenotype

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (actual)
• Sponsor: Inonu University · Academic / Other
• Sex: All
• Age: 18 Years – 45 Years
• Healthy volunteers: Not accepted

Summary

This clinical trial aims to evaluate the effects of injectable platelet-rich fibrin (I-PRF) and concentrated platelet-rich fibrin (C-PRF) on gingival phenotype in patients undergoing mucogingival surgery with the VISTA technique. Changes in gingival thickness and width of keratinized gingiva will be assessed using both manual and digital methods.

Detailed description

The study is designed as a randomized controlled clinical trial including 30 patients, divided into two groups: I-PRF and C-PRF. All participants receive a mucogingival procedure using the VISTA technique followed by four sessions of PRF injections (one during surgery and three at 10-day intervals). The primary outcomes are changes in gingival thickness and the width of keratinized gingiva, measured manually and digitally at baseline, 1 month, 3 months and 6 months. The aim is to compare the effectiveness of I-PRF and C-PRF on soft tissue enhancement.

Conditions

• Thin Gingival Biotype
• Thin Gingiva

Interventions

Type	Name	Description
BIOLOGICAL	Concentrated PRF	Injectable platelet-rich fibrin was prepared using low-speed centrifugation and injected using the same protocol as C-PRF (1 surgical + 3 injection sessions at 10-day intervals).
BIOLOGICAL	Injectable PRF	Injectable platelet-rich fibrin was prepared using low-speed centrifugation and injected using the same protocol as C-PRF (1 surgical + 3 injection sessions at 10-day intervals).

Timeline

• Start date: 2025-02-11
• Primary completion: 2025-07-15
• Completion: 2025-08-10
• First posted: 2025-05-09
• Last updated: 2026-03-27

Locations

1 site across 1 country: Turkey (Türkiye)