NCT06962657

Mitigating Toxic Impact: The Role of Coenzyme Q10 in Post-Exposure Protection

• Status: Not Yet Recruiting
• Phase: Phase 2
• Study type: Interventional
• Enrollment: 20 (estimated)
• Sponsor: University of California, San Diego · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

This research study is being conducted to see if coenzyme Q10 (a nutritional supplement) might help to prevent and/or alleviate symptoms and health consequences and help to improve quality of life and physical function in residents affected by the February 2023 East Palestine, Ohio train derailment. This is a pilot study that is not powered to achieve benefit but seek to examine effect size and variance to aid in power calculations for a potential future better powered study.

Conditions

• Toxicant Induced Chronic Multisymptom Illness and Associated Symptoms and Comorbidities

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Ubiquinone 100 mg Oral Soft Gel	Active comparator arm receives three ubiquinone 100mg soft gels per day. Supplement is taken orally in divided doses, with the last soft gel not close to bedtime.
DIETARY_SUPPLEMENT	Placebo	Placebo comparator arm receives three placebo soft gels per day. Supplement is taken orally in divided doses, with the last soft gel not close to bedtime.

Timeline

• Start date: 2025-07-01
• Primary completion: 2028-07-01
• Completion: 2028-07-01
• First posted: 2025-05-08
• Last updated: 2025-05-08

Locations

1 site across 1 country: United States