NCT06962605

Effects of Intermittent Running on Metabolic Health

Acute Effects of Intermittent vs. Continuous Running Exercise on Physiological and Metabolic Responses

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 16 (estimated)
• Sponsor: National Taiwan Normal University · Academic / Other
• Sex: Male
• Age: 20 Years – 45 Years
• Healthy volunteers: Accepted

Summary

The purpose of this study is to investigate the suitability of intermittent exercise of long and short intervals at lower intensities than HIIE on energy expenditure during and post-exercise compared to MICE, as well as determine whether similar or greater effects can be achieved for glycemic control in recreationally active adults.

Detailed description

The same procedure will be repeated for all trials: Participants will be asked to perform 3 trials in a randomized-crossover design \[moderate-intensity continuous running (MICE: 60% V̇O2max), 5-minute interval running (5MIN; 50% and 70% V̇O2max), 2-minute interval running (2MIN; 50% and 70% V̇O2max)\]. All trials will be separated by at least 4 days wash-out and less than 14 days between trials to ensure complete rest. Sensors for measuring muscle oxygen (10 cm proximal to the mid-patella, and 2 cm lateral) will be placed on the rectus femoris muscle and 15 min resting metabolic rate was measured. After baseline measurements, participants warm-up for 3 minutes with fixed walking intensity (i.e., 5 km/h) followed by 40 minutes running. Immediately after the running, participants return to a seated position for 30 minutes post-exercise measurements (EPOC). During the EPOC and resting metabolic rate (RMR) measurement participants will sit in a comfortable position and need to limit fidgeting, thus allowed only to watch TV or videos on their phone. Participants will be wheeled to the bathroom if needed.

Conditions

• Metabolic Regulation
• Energy Expenditure

Interventions

Type	Name	Description
BEHAVIORAL	Moderate-intensity continuous running (MICE: 60% V̇O2max)	Participants run continuously for 40 minutes at moderate intensity (60-65% V̇O2max)
BEHAVIORAL	5-minute interval running (5MIN)	Participants run for 40 minutes at average moderate intensity with 5-minutes slow and fast cycles where speed is increased and decreased by 20%.
BEHAVIORAL	2-minute interval running (2MIN)	Participants run for 40 minutes at average moderate intensity with 2-minutes slow and fast cycles where speed is increased and decreased by 20%.

Timeline

• Start date: 2025-06-21
• Primary completion: 2026-04-30
• Completion: 2026-04-30
• First posted: 2025-05-08
• Last updated: 2026-01-26

Locations

1 site across 1 country: Taiwan