NCT06962527

Test of Target Engagement of Ambiguity Aversion

Computational Modeling of Ambiguity Aversion in Internalizing Disorders: Neural and Behavioral Markers, and a Test of Target Engagement

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 140 (estimated)
• Sponsor: Northwestern University · Academic / Other
• Sex: All
• Age: 25 Years – 60 Years
• Healthy volunteers: Accepted

Summary

The present work aims to test whether a single session intervention alters ambiguity aversion, both in terms of people's decision making and their brain responses to ambiguous choices.

Detailed description

In this trial, participants will be randomized to one of two single session interventions (SSI). They will complete a decision making task before and after the SSI to measure their behavioral and brain responses to ambiguity, all on the same day. They will also complete a brief measure of hopelessness before and after the SSI. The main analysis will compare changes in ambiguity aversion before and after the interventions. Participants will also be asked to complete questionnaires before completing the task and SSI. The questionnaires will be about the participant's emotions and symptoms of depression and anxiety, personality, and avoidance/tolerance of uncertainty.

Conditions

• Intolerance of Uncertainty
• Anxiety
• Intolerance of Uncertainty; Anxiety
• Depression, Anxiety

Interventions

Type	Name	Description
BEHAVIORAL	Uncertainty-focused single session intervention	Digitally/computer administered 30-minute self-guided intervention for adults ages 25-60
BEHAVIORAL	Maintaining a healthy lifestyle single session intervention	Digitally/computer administered 30-minute self-guided intervention for adults ages 25-60

Timeline

• Start date: 2025-07-07
• Primary completion: 2029-07-01
• Completion: 2029-12-31
• First posted: 2025-05-08
• Last updated: 2025-11-21

Locations

1 site across 1 country: United States