NCT06960902

Study of the Determinants of Coronary Atherosclerosis in Familial Hypercholesterolemia (ATHERO-FH Study)

Study of the Determinants of Coronary Atherosclerosis in Familial Hypercholesterolemia

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 600 (estimated)
• Sponsor: Nantes University Hospital · Academic / Other
• Sex: All
• Age: 40 Years
• Healthy volunteers: Not accepted

Summary

The goal of this study (interventional clinical research not involving a health product) is to assess the prevalence of subclinical coronary atherosclerosis diagnosed by coronary CT angiography in heart failure patients in primary prevention, across different levels of cardiovascular risk defined by coronary artery calcium (CAC) score percentiles (based on data from the MESA study): low risk (≤25th percentile for age, sex, and ethnicity), intermediate risk (25th \< CAC ≤ 75th percentile), and high risk (\>75th percentile). The Patients will attend an on-site visit at inclusion (and must undergo a coronary CT angiography within 6 months following this visit), will be contacted by phone at 1 year and 2 years, and will return for an on-site visit at 30 months.

Conditions

• Familial Hypercholesterolemias
• Atherosclerotic Cardiovascular Disease (ASCVD)

Interventions

Type	Name	Description
OTHER	Coronary CT scan with CAC score measurement	Coronary CT scan with CAC score measurement (on the same day or within 6 months after the inclusion visit).

Timeline

• Start date: 2025-09-25
• Primary completion: 2027-03-25
• Completion: 2029-09-25
• First posted: 2025-05-07
• Last updated: 2026-03-19

Locations

9 sites across 1 country: France