NCT06960798

Characterizing the Genomic Landscape of Prostate Cancer in Native American Populations (NAT-Geno)

Characterizing the Genomic Landscape of Prostate Cancer in Native American Populations (Nat-Geno)

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 150 (estimated)
• Sponsor: University of Oklahoma · Academic / Other
• Sex: Male
• Age: 18 Years – 100 Years
• Healthy volunteers: Not accepted

Summary

The purpose of this study is to analyze tumor tissue samples from patients of Native American identity with prostate cancer. By examining these samples, researchers hope to understand how different genes in your tumor can influence treatment decisions, how your cancer progresses and the outcome of your cancer.

Detailed description

This study aims to establish a comprehensive database of Native American (NA) patients diagnosed with prostate cancer (PC), focusing on an in-depth characterization of the genomic landscape. Archived tumor tissue collected at screening and peripheral blood samples obtained within the first year of enrollment will serve as the basis for comprehensive molecular analyses. Whole exome sequencing (WES) and whole transcriptome sequencing (RNA-seq) will be performed to characterize and delineate the genomic and transcriptomic landscape of the study cohort. The study will initially enroll participants at the Stephenson Cancer Center, with planned expansion to additional sites across Oklahoma and, subsequently, to other institutions across the United States. Oversight will be maintained by the Tribal Institutional Review Board and an independent Community Advisory Board to ensure cultural appropriateness, transparency, and sustained community engagement throughout the research process. The overarching objective is to generate insights that will inform the development of personalized treatment strategies in the future.

Conditions

• Prostate Cancer

Interventions

Type	Name	Description
OTHER	Bio-specimen Collection	Tissue samples will be taken from existing archived collections and sent for further analysis.
OTHER	Blood Draw	Blood samples will be collected within the first year of enrollment.

Timeline

• Start date: 2026-05-02
• Primary completion: 2028-05-30
• Completion: 2029-06-30
• First posted: 2025-05-07
• Last updated: 2026-03-02

Locations

1 site across 1 country: United States