NCT06959407

Efficacy Of Oral Dexamethasone Versus Parenteral Dexamethasone In The Management Of Mild To Moderate Croup

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 200 (actual)
• Sponsor: Arooj Khan · Academic / Other
• Sex: All
• Age: 2 Years – 12 Years
• Healthy volunteers: Not accepted

Summary

Croup (laryngotracheobronchitis) is a viral infection of the upper airway that causes throat swelling, leading to a barking cough, stridor, and hoarseness. It mainly affects children aged 6 months to 12 years, peaking at around 2 years. Most cases are mild and self-limiting. Emergency treatments include cool mist, nebulized epinephrine, and steroids. Steroid therapy, particularly dexamethasone (oral or intramuscular), is commonly used, with recent studies suggesting intramuscular dexamethasone may be more effective. However, most research has focused on hospitalized patients, and there is a lack of local data for mild cases. This study aims to address that gap and improve patient counseling and future research

Conditions

• Laryngotracheobronchitis
• Croup

Interventions

Type	Name	Description
DRUG	oral dexamethasone	Patients in group A will receive oral dexamethasone which will be administered at 0.6mg/kg as single dose
DRUG	intramuscular dexamethasone	Patients in group B will receive intramuscular dexamethasone which will be administered in 0.6mg/kg strength as intra-gluteal injection as single dose

Timeline

• Start date: 2024-10-01
• Primary completion: 2025-03-01
• Completion: 2025-03-01
• First posted: 2025-05-06
• Last updated: 2026-01-29

Locations

1 site across 1 country: Pakistan