NCT06959017

Diffrence in Thromboprofilaksis in Elderly Ostoepenic Hip Fractures According to Mobility Status by Genetic Analysis

Is Thromboprotection Preserved in Elderly Ostopenic Patients Who Are Severly Immobilized Before Hip Fracture?

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 90 (estimated)
• Sponsor: Saglik Bilimleri Universitesi · Academic / Other
• Sex: All
• Age: 65 Years
• Healthy volunteers: Accepted

Summary

Hip fracture is a common and severe disease in elderly patients. The question of the study is whether elderly patients with severe osteopenia have significantly lower levels of the collagen-binding protein Hsp47 than relatively mobile patients due to advanced immobility before the fracture, and whether they participants have a similar risk of VTE to the normal population despite having had a hip fracture and surgery.

Detailed description

In this study, the investigators aimed to prospectively measure the Hsp 47 gene expression levels in patients scheduled for surgery due to intertrochanteric femur fracture and healthy volunteers in the same age group and compare the results with the literature. Also the complications prior or after surgery will be compared.

Conditions

• Hip Fracture of Intertrochanteric Type
• Thromboembolic Event
• Osteopenia
• Thrombosis Embolism

Interventions

Type	Name	Description
GENETIC	Gene Expression Analysis	Each subject analysed for SERPİNH1 and ROCK1 gene exppression

Timeline

• Start date: 2024-11-01
• Primary completion: 2025-06-01
• Completion: 2025-12-01
• First posted: 2025-05-06
• Last updated: 2025-06-05

Locations

1 site across 1 country: Turkey (Türkiye)