NCT06957964

Prophylactic Negative Pressure Wound Therapy in Laparotomy Wounds: A Randomized Clinical Trial

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 70 (estimated)
• Sponsor: Dr Hamail Khanum · Academic / Other
• Sex: All
• Age: 20 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

Total 70 participants meeting selection criteria will be enrolled in the study from operational theatre. They will be randomly divided in two groups by using lottery method. In group A, Negative Pressure Wound Therapy will be applied at end of procedure. In group B, no Negative Pressure Wound Therapy will be placed. They will be shifted to post-surgical wad for 72 hours and then will be discharged with prescription of standard antibiotics and will be followed-up in OPD for 30 days. If patient will develop surgical site wound infection, then it will be noted. If infection will not be cured with antibiotics course, then re-operation will be done. Patients complications will be managed as per hospital protocol. All this information will be recorded in proforma.

Conditions

• Wound
• Infection Prevention
• Negative Pressure Wound Therapy

Interventions

Type	Name	Description
OTHER	Negative Pressure Wound Therapy	Negative Pressure Wound Therapy is an intervention in which a suction is applied at applied thus creating a negative pressure which not only removes any exudate but also aids in formation of granulation tissue. NPWT is provided along with empirical prophylactic antibiotics
DRUG	Standard Antibiotic Treatment	According to hospital antibiogram, empirical antibiotics are given prophylactically

Timeline

• Start date: 2025-03-25
• Primary completion: 2025-06-25
• Completion: 2025-06-25
• First posted: 2025-05-06
• Last updated: 2025-05-06

Locations

1 site across 1 country: Pakistan