NCT06956430

Mitigating Heat Stress Among Rickshaw Drivers in Bangladesh

How Does Heat Stress Affect Telomere Length? A Pilot Randomized Controlled Trial in Urban Bangladesh

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 300 (estimated)
• Sponsor: University of California, Berkeley · Academic / Other
• Sex: Male
• Age: 40 Years
• Healthy volunteers: Not accepted

Summary

The goal of the experimental study is to understand the impact of heat stress on core temperature and telomere length. Investigators will recruit rickshaw drivers who use manual power to push their rickshaws and randomly assign half of them to receive battery-powered rickshaws to use for four months. Investigators will assess how this change impacts their core body temperature while they work, the length of their telomeres (caps on the end of DNA that are associated with aging), and kidney function.

Detailed description

Personal exposure to heat may be elevated above ambient temperatures if an individual is very active (which generates metabolic heat) or wears clothing that prevents cooling. Age can influence the consequences of heat stress. Older adults are at elevated risk of adverse impacts from heat stress due to their reduced ability to dissipate heat. Heat stress is particularly high among outdoor workers. South Asia has millions of bicycle rickshaw drivers, who use their muscles or battery power to pull hundreds of pounds of passengers and goods on modified bicycles. When manual rickshaw drivers rest to cool off, they reduce their already meager income. Heat stress not only threatens their livelihoods and thereby their right to an adequate standard of living but also their right to work, given that they have few employable skills other than manual labor. South Asia faces the greatest current and predicted loss in disability-adjusted life years due to heat stress, and heat stress is particularly strong in informal settlements. As such, the investigators plan to conduct this study in Dhaka, Bangladesh. The overall hypothesis is that driving a battery-powered rickshaw will reduce heat strain. The investigators will evaluate the impact of driving a battery-powered rickshaw on core temperature (primary outcome), telomere length, kidney function, heart rate, heart rate variability, sleep quality, self-reported thermal comfort, mental health, wellness, and fatigue (secondary outcomes).

Conditions

• Core Temperature
• Telomere Length, Mean Leukocyte
• Kidney Function Issue

Interventions

Type	Name	Description
DEVICE	Battery-powered rickshaw	A battery-powered rickshaw is a rickshaw where the wheels are turned by a small electric motors powered by a battery.

Timeline

• Start date: 2025-06-01
• Primary completion: 2025-10-31
• Completion: 2025-12-31
• First posted: 2025-05-04
• Last updated: 2025-05-21