NCT06955572

Descriptive Study of the Gene Count in Faecal Microbiota

Descriptive Study of the Gene Count in Faecal Microbiota During the Course of Various Pathologies and Correlation With the Clinical Phenotype

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 400 (actual)
• Sponsor: University Hospital, Rouen · Academic / Other
• Sex: All
• Age: 18 Years – 75 Years
• Healthy volunteers: Accepted

Summary

The hypothesis of METARICH Study is that it is possible to draw up a profile of the faecal microbiota, which could contribute in the future to the characterisation of certain chronic pathologies. The pathologies chosen for the study were selected because they are associated in the literature with changes in the faecal microbiota.

Detailed description

All the study data will be collected from the patients' clinical records and from the questionnaires set up (patient inclusion questionnaire and information questionnaire). * The patient inclusion questionnaires collect the following variables: characteristics of the pathology (precise phenotyping by the clinician, assessment of severity, age, progression) as well as biological parameters obtained in the patient's usual check-ups and current treatments specific to the pathology. * The patient information questionnaire collects information on lifestyle habits (smoking, alcohol, sporting activities, diet), stool sample data (Bristol scale, day and time of collection), treatment(s) received in the last 3 months and other chronic pathologies.

Conditions

• Microbiota

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	Patients with colorectal cancer	Analysis of the lower fecal gene count (fGC) compared with the control group
DIAGNOSTIC_TEST	Patients with Parkinson's disease	Analysis of the lower fecal gene count (fGC) compared with the control group
DIAGNOSTIC_TEST	Patients with non-alcoholic steatohepatitis	Analysis of the lower fecal gene count (fGC) compared with the control group
DIAGNOSTIC_TEST	Patients with obesity	Analysis of the lower fecal gene count (fGC) compared with the control group
DIAGNOSTIC_TEST	Healthy volunteers	Determination of the number of bacterial faecal genes (fGC, fecal Gene Count) inferior reference

Timeline

• Start date: 2023-02-28
• Primary completion: 2024-05-22
• Completion: 2024-07-22
• First posted: 2025-05-02
• Last updated: 2025-05-02

Locations

1 site across 1 country: France