NCT06954675

Comparison of Microbiome Changes in Healthy Adults Following Ketone Ester Consumption

Bacterial Responses to Enteric Alterations After Ketones

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 20 (estimated)
• Sponsor: University of California, San Francisco · Academic / Other
• Sex: All
• Age: 18 Years – 40 Years
• Healthy volunteers: Accepted

Summary

The goal of this observational study is to learn if a ketone ester can improve the content of the gut microbiome. The main questions it aims to answer are: * Does a ketone ester reduce age-related signatures in the gut microbiome? * What changes occur in the gut microbiome after consuming a ketone ester? Participants will: * Take a ketone ester every day for seven (7) days * Collect and ship stool samples within seven (7) days before, during, and within seven (7) days after the study period * Measure their ketone levels with a urine strip every day after having the drink * Answer questions about their typical diet on a normal day * Record their symptoms, if any arise

Conditions

• Microbiome Analysis

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Exogenous ketone ester	25g Bis-octanoyl-(R)-1,3-butanediol (C8)

Timeline

• Start date: 2025-11-21
• Primary completion: 2026-09-30
• Completion: 2026-09-30
• First posted: 2025-05-01
• Last updated: 2026-01-26

Locations

1 site across 1 country: United States