NCT06954376

Hyperbaric Oxygen Therapy as a Neuroprotective Intervention in Pediatric Acquired Brain Injury With Cognitive Disability

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 120 (actual)
• Sponsor: Kafrelsheikh University · Academic / Other
• Sex: All
• Age: 4 Years – 12 Years
• Healthy volunteers: Not accepted

Summary

This research aimed to investigate the effectiveness of hyperbaric oxygen therapy as a neuroprotective strategy for improving neurological outcomes in pediatric patients who have sustained acquired brain injury.

Detailed description

Hyperbaric oxygen therapy (HBOT) is a medical treatment that delivers high-concentration oxygen in a pressurized chamber. It was developed initially from diving physiology research and popularized by Dutch surgeon Boerema for its life-sustaining plasma oxygen diffusion under hyperbaric conditions. The fundamental mechanism of HBOT operates through Henry's Law, enabling unprecedented increases in tissue oxygen partial pressures that surpass levels achievable in normal atmospheric conditions.

Conditions

• Hyperbaric Oxygen Therapy
• Neuroprotective
• Pediatric
• Acquired Brain Injury
• Cognitive Disability

Interventions

Type	Name	Description
OTHER	Hyperbaric oxygen therapy	Patients received hyperbaric oxygen therapy (HBOT) using a monochamber hyperbaric chamber in addition to conventional rehabilitation.
OTHER	Conventional rehabilitation	Patients received conventional rehabilitation alone.

Timeline

• Start date: 2024-03-01
• Primary completion: 2024-10-01
• Completion: 2024-10-01
• First posted: 2025-05-01
• Last updated: 2025-05-01

Locations

1 site across 1 country: Egypt