NCT06952179

Pericardial Histopathology and COVID-19 Seropositivity

Pericardial Histopathology and COVID-19 Seropositivity in Adult Patients Undergoing First-Time Coronary Artery Bypass Grafting: A Prospective Study

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 93 (actual)
• Sponsor: Samsun University · Academic / Other
• Sex: All
• Age: 20 Years – 75 Years
• Healthy volunteers: —

Summary

This prospective study aims to investigate the association between pericardial histopathologic inflammation grades (acute, chronic, or absent) and COVID-19 seropositivity in adult patients undergoing first-time isolated coronary artery bypass grafting (CABG). Pericardial tissue samples were collected during surgery and evaluated histopathologically, while preoperative COVID-19 serological testing was performed. The primary outcome is to determine whether COVID-19 seropositivity is associated with the severity of pericardial inflammation. Patients with prior cardiac surgery, active COVID-19 infection, systemic inflammatory diseases, chronic immunosuppressive therapy, or malignancy were excluded from the study.

Conditions

• Inflammatory Response
• COVID-19
• Pericardial Disease

Timeline

• Start date: 2023-02-01
• Primary completion: 2024-02-01
• Completion: 2024-06-01
• First posted: 2025-04-30
• Last updated: 2025-04-30

Locations

1 site across 1 country: Turkey (Türkiye)