NCT06952140

Hemodynamic Effects of Ketone Esters in Patients With Sepsis Induced Cardiomyopathy

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 12 (estimated)
• Sponsor: Tor Biering-Sørensen · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Sepsis is a life-threatening organ dysfunction caused by a dysregulated host response to infection and is associated with a high mortality rate in the ICU. Sepsis induced cardiomyopathy (SICM) is a multi-factorial process that appears in approximately 50% of patients with sepsis/septic shock and is associated with increased mortality. It is suggested that ketone bodies are more efficient substrates of energy metabolism than glucose, with a lower oxygen consumption per ATP-molecule produced and that the failing human heart increases the capacity to metabolize ketones. Previous studies have found acute beneficial hemodynamic effects of ketone esters in patients with chronic heart failure and cardiogenic shock, respectively. Improved hemodynamics and reduced systemic oxygen consumption as an effect of ketone esters might be of great benefit in patients admitted to the ICU. Thus, the investigators aim to investigate the hemodynamic effects of ketone esters in patients with sepsis induced cardiomyopathy in this randomized, placebo-controlled, double-blinded, cross-over, acute intervention study. .

Conditions

• Sepsis Induced Cardiomyopathy

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Ketone ester	Ketone ester: 3-hydroxybutyrate as enteral bolus (500 mg/kg)
DIETARY_SUPPLEMENT	Placebo	Maltodextrin (isovolumic and isocaloric placebo) as enteral bolus

Timeline

• Start date: 2026-03-10
• Primary completion: 2027-07-01
• Completion: 2027-12-31
• First posted: 2025-04-30
• Last updated: 2026-03-04