NCT06950372

Ropivacaine Concentration and Rebound Pain

Rebound Pain After Volar Plate Surgery in Infraclavicular Brachial Plexus Block With Ropivacaine 3.75 mg/ml Compared With 7.5 mg/ml. A Prospective, Parallelgroup, 2-arm, Triple Blinded Randomised Controlled Trial

• Status: Recruiting
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 80 (estimated)
• Sponsor: Oslo University Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

The goal of this clinical trial is to see if the concentration of a local anesthetic (ropivacaine) in peripheral nerve block is related to the severness of pain after surgery of distal radius fractures in adults. The main questions it aims to answer are: * Is concentration of ropivacaine related to severeness, duration and type of postoperative pain? * Is concentration of ropivacaine related to analgetic consumption after surgery? * Is concentration of ropivacaine related to block sucess rate during surgery and patient satisfaction after surgery? Researchers will compare ropivacaine 3.75 mg/ml and 7.5 mg/ml used in brachial plexus peripheral nerve block. Participipants are randomized to one of the two concentrations. The peripheral nerve block is standard anesthetic treatment for distal radius fractures scheduled for volar plate surgery at Oslo University Hospital. All other treatment for the condition will be the same as standard treatment. Participants will answer a questionnaire regarding pain, physical function, medication and life quality at different points of time after surgery, up to 6 weeks after surgery.

Conditions

• Radius Fracture Distal
• Rebound Pain

Interventions

Type	Name	Description
DRUG	Ropivacaine concentration low	Brachial plexus nerve block with ropivacaine 3.75 mg/ml
DRUG	Ropivacaine concentration high	Brachial plexus nerve block with ropivacaine 7.5 mg/ml

Timeline

• Start date: 2025-02-14
• Primary completion: 2026-12-01
• Completion: 2026-12-01
• First posted: 2025-04-30
• Last updated: 2025-04-30

Locations

1 site across 1 country: Norway