NCT06950164

Dynamic Changes of Ductus Arteriosus in < 31 Weeks Preterm Infants: an Observational Study

• Status: Active Not Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 200 (estimated)
• Sponsor: Daping Hospital and the Research Institute of Surgery of the Third Military Medical University · Academic / Other
• Sex: All
• Age: 1 Minute – 1 Hour
• Healthy volunteers: Not accepted

Summary

The ductus arteriosus quickly closes itself. is an important channel connecting the maternal fetal circulation before birth. After birth, this ductus arteriosus generally no longer has a physical function, so ductus arteriosus quickly closes itself. The persistent presence of ductus arteriosus leads to significant pressure changes in the systemic and pulmonary circulation, which have adverse effects on extremely/very premature infants. Therefore, persistent patent ductus arteriosus (PDA) is a systemic disease.

Detailed description

hemodynamic significant PDA(hsPDA) is a risk factor for intraventricular hemorrhage(IVH), bronchopulmonary dysplasia(BPD), necrotizing enterocolitis(NEC). A meta-analysis from Cochrane shows that compared to conservative treatment, drug therapy for PDA within 3 and 7 days after birth does not promote PDA closure and reduce the incidence of BPD. Therefore, there is currently a tendency not to provide medication intervention. Although ductus arteriosus quickly closes itself after birth in normal term infants, however, the dynamic changes detail of ductus arteriosus in preterm infants are unknown.

Conditions

• Preterm
• Ductus Arteriosus

Interventions

Type	Name	Description
OTHER	observation group	in the group, no intervention was given, and the preterm infants were diagnosed with respiratory distress syndrome(RDS)
OTHER	control group	in the group, no intervention was given, but the preterm infants were diagnosed without respiratory distress syndrome(RDS)

Timeline

• Start date: 2025-04-01
• Primary completion: 2026-04-30
• Completion: 2026-04-30
• First posted: 2025-04-30
• Last updated: 2025-04-30

Locations

1 site across 1 country: China