NCT06948136

Acute Effects of THC in Older Adult

• Status: Recruiting
• Phase: Phase 1
• Study type: Interventional
• Enrollment: 60 (estimated)
• Sponsor: Yale University · Academic / Other
• Sex: All
• Age: 21 Years
• Healthy volunteers: Accepted

Summary

The primary objective of this study is to determine if increasing age confers greater vulnerability to the acute A) cognitive (e.g., memory, attention, psychomotor function), B) subjective (e.g., anxiogenic and rewarding effects), and C) cardiovascular (heart rate and blood pressure), effects of THC in adults \> 21 years old. The secondary aims of the study are to explore age-related acute effects of THC on electrophysiological indices of information processing (e.g., auditory steady-state response (ASSR), oddball paradigm \[P300\], and resting state cortical noise) and to determine age-related differences in the metabolism of THC.

Conditions

• Age-related Cognitive Decline

Interventions

Type	Name	Description
DRUG	Delta-9-THC Low Dose	Active Delta-9-THC administered intravenously over 20 minutes.
DRUG	Placebo	Small amount of sterile ethanol (1-2 mLs), with no THC, administered intravenously over 20 minutes.
DRUG	Delta-9-THC Medium Dose	Active Delta-9-THC administered intravenously over 20 minutes

Timeline

• Start date: 2025-06-06
• Primary completion: 2027-11-01
• Completion: 2027-11-01
• First posted: 2025-04-29
• Last updated: 2025-08-18

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study