NCT06945627

Profiling Vulnerability and Resilience for Mental Illness Following Viral Infections

Profiling Vulnerability and Resilience for Mental Illness Following Viral Infections: Translating Epidemiology to Deep-phenotyping

• Status: Active Not Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 408,551 (actual)
• Sponsor: Sara Poletti · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

This observational study aims to identify the underlying neurobiological and environmental mechanisms that influence vulnerability or resilience to mental illness in the context of infection and their contribution to severe infective outcomes in people with pre-existing mental illness. The main questions it aims to answer are: * How do viral infections influence the development of mental illness? * What neurobiological and environmental factors contribute to influence the development of mental illness following infection? * How do these factors relate to the severity of infectious illness in people with pre-existing mental disorders? Researchers will move from large population databases to well-defined, deeply characterised samples to explore the association between infection and subsequent mental health outcomes, and the biological mechanisms behind these changes. Participants's data has already been collected.

Conditions

• Severe Mental Illness
• Inflammation
• Viral Infections
• Mood Disorders
• Schizophrenia

Interventions

Type	Name	Description
OTHER	This research doesn't involve any kind of intervention on the study participants	This research doesn't involve any kind of intervention on the study participants

Timeline

• Start date: 2024-05-02
• Primary completion: 2026-05-01
• Completion: 2027-03-01
• First posted: 2025-04-25
• Last updated: 2025-05-14

Locations

4 sites across 4 countries: Belgium, Israel, Italy, Norway