NCT06944847

Vaping and Smoking Project in People With Schizophrenia

A Laboratory Study of Behavior and Performance Among People Who Vape Nicotine and/or Smoke Cigarettes - Schizophrenia Supplement

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 64 (estimated)
• Sponsor: State University of New York at Buffalo · Academic / Other
• Sex: All
• Age: 21 Years – 50 Years
• Healthy volunteers: Not accepted

Summary

The proposed research will characterize withdrawal among people with schizophrenia who vape daily compared to people with schizophrenia who smoke combustible cigarettes daily, filling critical gaps in the understanding of electronic nicotine delivery systems (ENDS) dependence and contributing to the development of vaping cessation interventions amongst people with schizophrenia, the leading preventable cause of death in the US.

Detailed description

Although withdrawal is considered a key feature of nicotine/tobacco addiction that contributes to difficulty quitting smoking and likely electronic nicotine delivery systems (ENDS; e.g., electronic cigarettes), there is currently no research on ENDS withdrawal in people with schizophrenia. The proposed supplement will conduct a systematic and comprehensive characterization of withdrawal in a sample of people with SCZ who vape daily compared to those who smoke daily, filling gaps in our understanding of ENDS dependence/withdrawal for people with SCZ and contributing to the identification of intervention targets for ENDS use.

Conditions

• Acute Abstinence From Cigarettes vs E-cigarettes (ENDS)

Interventions

Type	Name	Description
BEHAVIORAL	Acute (24-hour) abstinence	Participants will be asked to abstain from all tobacco/nicotine for 24 hours prior to the visit
BEHAVIORAL	Ad libitum smoking/vaping	Participants will be asked to smoke/vape as usual during the 24 hours prior to the visit

Timeline

• Start date: 2025-02-15
• Primary completion: 2027-04-01
• Completion: 2027-04-01
• First posted: 2025-04-25
• Last updated: 2026-03-09

Locations

1 site across 1 country: United States