NCT06944132

CsA vs MMC for Preventing Pterygium Recurrence

Adjunctive Use of Topical Cyclosporin A Versus Mitomycin C to Prevent Pterygium Recurrence

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 40 (actual)
• Sponsor: Benha University · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

aimed to compare the efficacy and safety of topical cyclosporin A (CsA) versus mitomycin C (MMC) as adjunctive therapies in preventing pterygium recurrence after surgical excision.

Detailed description

A total of 40 eyes from 40 patients undergoing pterygium surgery were randomized into two groups: Group A received topical cyclosporin A, while Group B was treated with topical mitomycin C. Ocular surface inflammation scores, recurrence rates, patient-reported symptoms, and adverse effects were assessed at baseline and during follow-up at 6 months postoperatively.

Conditions

• Pterygium
• Pterygium of the Conjunctiva and Cornea

Interventions

Type	Name	Description
PROCEDURE	Excision of the pterygium	The surgical procedure involved excision of the pterygium, including the fibrovascular head and associated conjunctival tissue, followed by bare sclera closure using an autologous conjunctival graft harvested from the superior bulbar conjunctiva. The graft was secured in place using either fibrin glue or 8-0 absorbable sutures. In Group B, 0.02% mitomycin C (MMC) was applied to the bare sclera for two minutes using a soaked sponge, followed by thorough irrigation with balanced salt solution.
DRUG	Post-operative application of CsA	Patients received topical cyclosporin A (0.05%) twice daily for three months postoperatively.
DRUG	Intra-operative application of MMC	0.02% mitomycin C (MMC) was applied to the bare sclera for two minutes using a soaked sponge, followed by thorough irrigation with balanced salt solution.

Timeline

• Start date: 2024-04-01
• Primary completion: 2024-09-30
• Completion: 2024-10-15
• First posted: 2025-04-25
• Last updated: 2025-04-25

Locations

1 site across 1 country: Egypt