NCT06942026

Effects of Chlorhexidine Gluconate, Ozonated Water and Hypochlorous Acid Solutions Used in the Oral Care of Patients Supported by Mechanical Ventilation on the Integrity of the Oral Mucosa

• Status: Not Yet Recruiting
• Phase: Phase 4
• Study type: Interventional
• Enrollment: 63 (estimated)
• Sponsor: Aydin Adnan Menderes University · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Accepted

Summary

The purpose of this clinical trial is to learn whether ozonated water and hypochlorous acid solution can restore the integrity of the oral mucosa. In addition, the investigators will learn about the safety of ozonated water and hypochlorous acid solution. The main questions that participants need to answer are: What medical conditions do participants have while taking ozonated water and hypochlorous acid solution? Investigators will compare ozonated water and hypochlorous acid solution with 0.12% chlorhexidine gluconate solution to see if it helps to restore the integrity of the oral mucosa. Participants: Participants will be asked to agree to receive oral care 4 times a day, every day for 1 week.

Conditions

• Oral Mucosal Disorder

Interventions

Type	Name	Description
DRUG	Control 1	Researchers will perform oral care with ozonated water and hypochlorous acid solution to restore oral mucous membrane integrity.

Timeline

• Start date: 2025-04-27
• Primary completion: 2025-05-30
• Completion: 2025-09-30
• First posted: 2025-04-24
• Last updated: 2025-04-24

Locations

1 site across 1 country: Turkey (Türkiye)