NCT06941961

iTBS for Acute Ischemic Stroke After Thrombectomy

Efficacy and Safety of Intermittent Theta Burst Stimulation in Acute Anterior Circulation Ischemic Stroke Patients Undergoing Mechanical Thrombectomy

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 178 (estimated)
• Sponsor: Yi Yang · Academic / Other
• Sex: All
• Age: 18 Years – 85 Years
• Healthy volunteers: Not accepted

Summary

The goal of this randomized, single-blind, parallel-controlled clinical trial is to evaluate the efficacy and safety of intermittent theta burst stimulation (iTBS) as an adjunctive therapy for acute anterior circulation ischemic stroke patients who have undergone successful mechanical thrombectomy (MT). The study population includes adults aged 18-85 with NIHSS scores 5-25 post-MT and eTICI≥2b reperfusion.

Conditions

• Ischemic Stroke

Interventions

Type	Name	Description
DEVICE	intermittent theta burst stimulation	The iTBS delivered to the ipsilesional primary motor cortex (M1) at 80% resting motor threshold (RMT). Each session consists of 600 pulses (3-minute trains of 50 Hz triplets repeated every 10 seconds, twice daily with a 5-minute interval), administered for 7 consecutive days starting within 6 hours post-randomization.
DEVICE	sham intermittent theta burst stimulation	Sham-iTBS is performed in the same way as the treatment group but uses 20% RMT.

Timeline

• Start date: 2025-04-25
• Primary completion: 2026-07-01
• Completion: 2026-08-01
• First posted: 2025-04-24
• Last updated: 2025-04-30

Locations

1 site across 1 country: China