NCT06941038

Intraoperative vs. Postoperative Intravesical Epirubicin Instillation for Prevention of Bladder Recurrence in High-Risk Upper Urinary Tract Urothelial Carcinoma

Effect of Intravesical Chemotherapy on Disease Recurrence in Patients Undergoing Nephroureterectomy for Upper Urinary Tract Urothelial Carcinoma

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 270 (actual)
• Sponsor: Ankara Etlik City Hospital · Other Government
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

Upper urinary tract urothelial carcinoma (UTUC) accounts for 5%-10% of urothelial malignancies, with up to 50% of patients developing bladder recurrence post-RNU. High-risk UTUC (≥pT2, high-grade, or N+ disease) necessitates aggressive management. Intravesical chemotherapy mitigates recurrence risk, yet optimal timing-intraoperative vs. postoperative-remains unclear. This study evaluates intraoperative epirubicin instillation during RNU compared to postoperative administration and no instillation.

Conditions

• Bladder Cancer Recurrence
• Intravesical Instillation
• Upper Urinary Tract Carcinoma

Timeline

• Start date: 2021-06-01
• Primary completion: 2024-04-01
• Completion: 2024-06-20
• First posted: 2025-04-23
• Last updated: 2025-04-23

Locations

1 site across 1 country: Turkey (Türkiye)