NCT06939582

Hydroxychloroquine Sulfate Tablets for Radiation-induced Oral Mucositis

A Single Center, Open Label Phase II Clinical Trial of Hydroxychloroquine Sulfate Tablets for the Treatment of Radiation Stomatitis and Taste Disturbance in Intensity Modulated Radiotherapy for Head and Neck Cancer

• Status: Recruiting
• Phase: Phase 1 / Phase 2
• Study type: Interventional
• Enrollment: 158 (estimated)
• Sponsor: Xingchen Peng · Academic / Other
• Sex: All
• Age: 18 Years – 80 Years
• Healthy volunteers: Not accepted

Summary

Evaluate the safety, tolerance and efficacy of hydroxychloroquine sulfate tablets the prevention and treatment of oral mucositis and dysgeusia in patients undergoing radiotherapy

Conditions

• Radiation-induced Oral Mucositis

Interventions

Type	Name	Description
DRUG	Hydroxychloroquine Sulfate Tablets	the trial group use the hydroxychloroquine sulfate tablets (200mg/time, bid)
OTHER	Placebo	the control group use the Placebo

Timeline

• Start date: 2024-12-22
• Primary completion: 2025-06-01
• Completion: 2025-06-20
• First posted: 2025-04-23
• Last updated: 2025-04-29

Locations

1 site across 1 country: China