NCT06938932

Effects of Environmental Heat Exposure on Human Multiple Organ Function

Exposure to Environmental Heat and Intervention Study

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 24 (estimated)
• Sponsor: Yinan Qu · Academic / Other
• Sex: All
• Age: 18 Years – 30 Years
• Healthy volunteers: Accepted

Summary

This is a randomized controlled human exposure crossover study. Investigators aims to assess the acute effects of high temperature exposure and the underlying mechanisms.

Detailed description

The objective of this study is to study changes in functions of multiple organs under heat exposure, which mainly include changes of cardiac function and lung function. In addition, biological samples such as blood samples, nasal fluid, and urine, etc were collected to explore changes in biomarkers such as complete blood count, liver function, kidney function, and inflammatory indicators, etc. Biochemical analysis and omics analysis were conducted to study the changes of human physiological function caused by heat exposure.

Conditions

• Heat Stress Disorders
• Wounds and Injuries
• Body Temperature Changes
• Multiple Organ Dysfunction

Interventions

Type	Name	Description
OTHER	High temperature exposure	Subjects will be exposed to 35 degree Celsius and 45% relative humidity for 3 hours, resting during the whole periods.
OTHER	Moderate temperature exposure	Subjects will be exposed to 24degree Celsius and 45% relative humidity for 3 hours, resting during the whole periods.

Timeline

• Start date: 2025-04-21
• Primary completion: 2027-12-31
• Completion: 2027-12-31
• First posted: 2025-04-22
• Last updated: 2025-04-22

Locations

1 site across 1 country: China