NCT06938789

How Bleeding Affects Delirium in Older Patients With Hip Fractures: The IMPROVE-HIP Study

The Impact of Bleeding on Delirium Outcomes in Older Patients With Hip Fractures: A Single-Blind, Randomized Controlled Trial - The IMPROVE-HIP Study

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 198 (estimated)
• Sponsor: University of Aarhus · Academic / Other
• Sex: All
• Age: 75 Years
• Healthy volunteers: Not accepted

Summary

The goal of this clinical trial is to investigate whether early detection of bleeding and prompt blood transfusions can help prevent delirium in patients aged 75 and older who are admitted to the hospital with hip fractures. The main question the trial aims to answer is: • Do patients aged 75 and older with hip fractures benefit from quicker treatment of anaemia (low blood count) to reduce the risk of delirium? Researchers will compare early diagnosis and treatment of bleeding with standard care to determine if it helps lower the risk of developing delirium. Participants will: * Undergo blood tests and have their vital signs checked, as well as be screened for delirium three times a day for the first 48 hours after surgery. * Receive blood transfusions promptly if their haemoglobin levels drop below a specified threshold. * Have a follow-up visit at 30 days to assess their memory and overall quality of life. * Have another follow-up at 90 days to check for hospital readmissions and survival

Conditions

• Bleeding
• Hip Fracture
• Delirium - Postoperative

Interventions

Type	Name	Description
OTHER	Blood Transfusion	Blood transfusion is given without delay (within 4 hours) in case of hemoglobin below our threshold.
OTHER	Standard care	These patients recieve our standard care including blood transfusion as usual. Vital parameters and delirium screening are collected three times a day.

Timeline

• Start date: 2025-04-01
• Primary completion: 2025-12-01
• Completion: 2026-03-01
• First posted: 2025-04-22
• Last updated: 2025-04-22

Locations

2 sites across 1 country: Denmark