NCT06937671

Randomized Trial of Cold EMR Compared to Hybrid Cold EMR.

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 194 (estimated)
• Sponsor: The Cleveland Clinic · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The goal of this randomized clinical trial is to learn if a combination of hot and cold EMR technique is associated with a lower risk of polyp recurrence without increasing the risk of complication when removing large polyps. Participants will undergo EMR and return for a follow-up endoscopy in 3-6 months to check for polyp recurrence.

Conditions

• Polyp of Colon
• Endoscopic Mucosal Resection

Interventions

Type	Name	Description
PROCEDURE	Cold EMR	Cold EMR with cold forceps (regular or jumbo forceps) removal of any visible neoplasia that cannot be ensnared.
PROCEDURE	Hybrid EMR	Cold EMR with hot avulsion of any visible residual neoplasia within the resection bed, in addition to precise APC of the fibrotic bands that may harbor invisible neoplasia within the resection bed.

Timeline

• Start date: 2025-05-01
• Primary completion: 2026-12-01
• Completion: 2026-12-01
• First posted: 2025-04-22
• Last updated: 2025-11-20

Locations

2 sites across 1 country: United States