NCT06934473

Effects of Endogenous GIP on Postprandial Blood Pressure in Healthy Individuals

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 16 (estimated)
• Sponsor: University Hospital, Gentofte, Copenhagen · Academic / Other
• Sex: All
• Age: 18 Years – 40 Years
• Healthy volunteers: Accepted

Summary

The present study investigates the postprandial role of endogenous glucose-dependent insulinotropic polypeptide (GIP) on cardiovascular haemodynamics, hormone responses, and hypotensive symptoms during a tilt test.

Detailed description

The study is an exploratory, randomised, placebo-controlled, double-blinded crossover study comprising four experimental days. Each experimental day consists of a mixed meal test or drinking water, a double-blinded continuous infusion of GIP(3-30)NH2 or placebo or GIP(1-42) or placebo, and three tilt tests. Sixteen healthy men and women will be included in the study.

Conditions

• Bloodpressure

Interventions

Type	Name	Description
OTHER	GIP(3-30)NH2 / study tool	Selective antagonist of the GIPR, GIP(3-30)NH2
OTHER	Saline (NaCl 0,9 %) (placebo)	Placebo (NaCl 0,9%)
OTHER	GIP(1-42)	Agonist of the GIPR, GIP(1-42)

Timeline

• Start date: 2025-05-21
• Primary completion: 2026-01-31
• Completion: 2026-01-31
• First posted: 2025-04-18
• Last updated: 2025-09-08

Locations

2 sites across 1 country: Denmark