NCT06932211

A Study to Measure the Effect of a Toothpaste Containing Proteins and Enzymes and a Fluoride Toothpaste on Gingival Health

• Status: Completed
• Phase: N/A
• Study type: Interventional
• Enrollment: 251 (actual)
• Sponsor: Unilever R&D · Industry
• Sex: All
• Age: 18 Years – 70 Years
• Healthy volunteers: Accepted

Summary

This study is a double-blind, randomised, parallel group efficacy study. A minimum of 240 healthy female and male participants aged 18-70 years will be enrolled onto the study according to the inclusion/exclusion criteria. The accepted participants will then be randomly allocated to one of the two test products which they will use at home, twice a day for the duration of the study. Dental assessments of gingival condition and plaque level will be conducted after 4, 13 and 26 weeks of product use at the study site.

Conditions

• Gingival Inflammation
• Dental Plaque

Interventions

Type	Name	Description
OTHER	Toothpaste containing proteins and enzymes	Toothpaste containing proteins, enzymes and 1450 ppm fluoride as sodium fluoride
OTHER	Control fluoride toothpaste	Toothpaste containing sodium fluoride at 1450 ppm F

Timeline

• Start date: 2018-10-29
• Primary completion: 2019-04-30
• Completion: 2019-04-30
• First posted: 2025-04-17
• Last updated: 2025-04-17

Locations

1 site across 1 country: China