NCT06929793

Multiple Micronutrients Supplementation on Angiogenesis and Vasculogenesis Factors, and Fetal Biometry

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 200 (actual)
• Sponsor: Dr Cipto Mangunkusumo General Hospital · Academic / Other
• Sex: Female
• Age: —
• Healthy volunteers: Accepted

Summary

Multiple micronutrients play an important role during pregnancy, since the decidualization and implantation phases. It has an impact on placentation and remodeling of blood vessels. The optimal early pregnancy conditions accompanied by great angiogenesis and vasculogenesis factors will influence fetal growth. This study aims to determine the effect of maternal multiple micronutrient supplementation on angiogenesis factors, vasculogenesis factors, and fetal biometry. It is a clustered randomized controlled trial that aims to determine the impact of maternal micronutrient supplementation on PlGF levels, sFlt-1/PlGF ratio, mean pulsatility index of uterine artery, and fetal biometry (head circumference, femur length, and estimated fetal weight percentile). The target population for the study was all pregnant women who underwent antenatal check-ups at community health centers in DKI Jakarta.

Conditions

• Angiogenesis
• Fetal Weight
• Pregnancy Related
• Nutrient Element Deficiency
• High Risk Pregnancy

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Multiple Micronutrients	1. Multiple micronutrient 2. Calcium Carbonat 766 mg 3. Vitamin D3 5000 IU 4. DHA 300 mg
DRUG	Standard Antenatal Vitamin	Standard Antenatal Vitamin given in Community Health Centers

Timeline

• Start date: 2024-03-01
• Primary completion: 2025-05-30
• Completion: 2025-06-30
• First posted: 2025-04-16
• Last updated: 2025-04-16

Locations

1 site across 1 country: Indonesia