NCT06929442

A Preventive Behavioral Intervention for Young Adults With Psychotic Experiences

A Randomized Controlled Trial of a Preventive Behavioral Intervention for Young Adults With Psychotic Experiences

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 192 (estimated)
• Sponsor: Massachusetts General Hospital · Academic / Other
• Sex: All
• Age: 18 Years – 30 Years
• Healthy volunteers: Not accepted

Summary

This is a randomized controlled trial testing the efficacy of Resilience Training in college students with elevated transdiagnostic risk for developing a serious mental illness.

Detailed description

This is a definitive, randomized controlled trial that will measure the efficacy of Resilience Training, a four-session group-based behavioral intervention conducted in transdiagnostically at-risk young adults who have psychotic experiences. The primary goal is to determine whether Resilience Training is superior to a time-matched active control condition, Life Skills Training, in reducing transdiagnostic symptoms of psychopathology, such as psychotic experiences, and improving long-term psychiatric (preventing the onset of psychiatric diagnoses) and functional (improving academic performance and retention in college) outcomes in this at-risk population. In addition, a proposed model of the mechanisms of action of RT, involving reducing emotion reactivity and changes in hippocampal function and connectivity, will be assessed.

Conditions

• Psychotic Disorders
• Mood Disorders
• Anxiety Disorders

Interventions

Type	Name	Description
BEHAVIORAL	Resilience Training (RT)	RT is a 4-week program of weekly 90-minute sessions in which participants are taught the following skills: mindfulness, self-compassion and mentalization.
BEHAVIORAL	Life Skills Training (LST)	LST is a 4-week program of weekly 90-minute sessions, in which participants are provided information about helpful life skills, including financial literacy, health, physical and internet safety.

Timeline

• Start date: 2025-02-10
• Primary completion: 2028-12-01
• Completion: 2029-06-01
• First posted: 2025-04-16
• Last updated: 2026-04-17

Locations

1 site across 1 country: United States