NCT06928233

Association of TNFAIP3 With Immune-mediated TTP

Association of the TNFAIP3 Genomic Locus With Immune-mediated TTP

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 400 (estimated)
• Sponsor: Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico · Academic / Other
• Sex: All
• Age: 12 Years
• Healthy volunteers: Accepted

Summary

This study aims to investigate whether genetic variation in the TNFAIP3 locus is associated with immune-mediated thrombotic thrombocytopenic purpura (iTTP), and whether such association is mediated by decreased expression of A20 (TNFAIP3). The study includes a case-control design to assess genotype-expression association and a cohort study to evaluate clinical outcomes such as disease relapse.

Conditions

• Thrombotic Thrombocytopenic Purpura, Acquired

Interventions

Type	Name	Description
PROCEDURE	blood sampling	Blood sampling for experimental analyses.

Timeline

• Start date: 2025-04-07
• Primary completion: 2026-04-01
• Completion: 2026-04-01
• First posted: 2025-04-15
• Last updated: 2026-03-27

Locations

1 site across 1 country: Italy