NCT06926439

Prediction of Detoxification Effect of Fat Emulsion Based on Drug Diffusion Law

Prediction of Detoxification Effect of Fat Emulsion Based on Drug Diffusion Law: Clinical Observational Study

• Status: Active Not Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 85 (estimated)
• Sponsor: The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School · Academic / Other
• Sex: All
• Age: 18 Years – 85 Years
• Healthy volunteers: Not accepted

Summary

The goal of this observational study is to establish a predictive model for the clinical use value of fat emulsion as an antidote based on the physical information of fat emulsion on drug diffusion process. The main question it aims to answer is: Observing the effect of fat emulsion on the pharmacokinetic changes of overdose drugs; Observe and evaluate the therapeutic effect of long-chain fat emulsion as an antidote; Participants will have their whole blood samples collected for toxicology testing.

Conditions

• Poisoning
• Toxicokinetics
• Lipid Emulsion

Interventions

Type	Name	Description
DRUG	Long chain lipid emulsion	For patients presenting with fat soluble drug overdose, administer a weight-based infusion of long-chain lipid emulsion at 0.05 ml/kg/min for 1 hour, not to exceed a total of 250 mL.

Timeline

• Start date: 2024-06-01
• Primary completion: 2027-05-31
• Completion: 2027-05-31
• First posted: 2025-04-13
• Last updated: 2025-04-13

Locations

1 site across 1 country: China