NCT06924242

Thyroid Cancer in Surgical Treated Multinodular Goiter

Thyroid Cancer in Surgically Treated Multinodular Goiter: Incidence and Histopatological Outcomes

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 223 (actual)
• Sponsor: University of Foggia · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Accepted

Summary

This study aims to investigate, based on existing knowledge, the incidence of occult thyroid carcinoma in a cohort of patients with MNG, providing new insights into the prevalence and characteristics of thyroid malignancies in MNG. It seeks to contribute to optimizing diagnostic evaluations for patients with multinodular goiter.

Detailed description

This retrospective study included patients with a preoperative diagnosis of multinodular goiter who underwent total or partial thyroidectomy from January 2018 to May 2024 at the Department of Medical and Surgical Sciences at the University Hospital "Ospedali Riuniti" in Foggia. The study's objective was to investigate the incidence of thyroid carcinoma in patients undergoing thyroidectomy for MNG, also analyzing associated demographic and clinical variables.

Conditions

• Goiter, Nodular
• Total Thyroidectomy
• Thyroid Cancer

Interventions

Type	Name	Description
PROCEDURE	total or partial thyroidectomy	Total thyroidectomy is a surgical procedure that involves the complete removal of the thyroid gland. It is performed to treat conditions such as thyroid cancer, large goiters, or severe hyperthyroidism. The surgery is typically conducted under general anesthesia through an incision in the lower neck. Postoperative management may include hormone replacement therapy with levothyroxine to compensate for the loss of thyroid function. Potential complications include hypocalcemia due to parathyroid gland injury and vocal cord dysfunction from recurrent laryngeal nerve damage.

Timeline

• Start date: 2018-01-01
• Primary completion: 2024-05-30
• Completion: 2024-07-31
• First posted: 2025-04-11
• Last updated: 2025-04-11

Locations

1 site across 1 country: Italy