NCT06923397

Interrupting Sedentary Time to Improve Cardiometabolic Health and Toxicity in Patients With Lymphoma Receiving Chemotherapy: The iSTAND Trial

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 24 (estimated)
• Sponsor: Dana-Farber Cancer Institute · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

This study aims to see if a 12-week exercise program designed to reduce long periods of inactivity is feasible in newly diagnosed lymphoma participants receiving R-CHOP or POLA-R-CHP chemotherapy treatments, and whether it can improve heart health and reduce chemotherapy drug side effects.

Detailed description

The purpose of this study is to see if a 12-week exercise program designed to reduce long periods of inactivity is feasible in newly diagnosed lymphoma participants receiving R-CHOP or POLA-R-CHP chemotherapy treatments, and whether it can improve heart health and reduce chemotherapy drug side effects. Participants will be randomized into one of two groups: Group A: Interrupted Sedentary Time Intervention vs. Group B: Usual Care Control Group. Randomized means a participant is placed into a study group by chance. The research study procedures include screening for eligibility, assessments of fitness and physical health, blood tests, and questionnaires. Participation in this research study is expected to last about 3 months. It is expected that about 24 people will take part in this research study.

Conditions

• Lymphoma
• Lymphoma, Hodgkin
• Lymphoma, Non-Hodgkin
• Sedentary Behavior

Interventions

Type	Name	Description
BEHAVIORAL	Interrupted Sedentary Time Intervention	A 12-week, semi-supervised exercise intervention comprised of reminder prompts, counseling, and activities of walking, cycling, and resistance band exercise for at-home and in-clinic settings. Supervision will be under an exercise trainer. Resistance bands, Libre Pro continuous blood sugar monitor, and Fitbit and ActivPAL trackers will be provided to participants.

Timeline

• Start date: 2025-06-05
• Primary completion: 2026-11-28
• Completion: 2026-12-31
• First posted: 2025-04-11
• Last updated: 2026-04-13

Locations

1 site across 1 country: United States