NCT06921980

Brain Function and Psychological Changes Related to Cell Therapy for Autoimmune Hemolytic Anemia

Brain Function and Psychological Assessment in Patients With Autoimmune Hemolytic Anemia Undergoing Cell Therapy

• Status: Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 20 (estimated)
• Sponsor: Institute of Hematology & Blood Diseases Hospital, China · Academic / Other
• Sex: All
• Age: 18 Years – 65 Years
• Healthy volunteers: Not accepted

Summary

Cell therapy is an innovative treatment with significant efficacy in hematologic and certain autoimmune diseases. Although it offers potential benefits for autoimmune hemolytic anemia (AIHA), it may result in cognitive and other potential impairments, which can adversely affect patients' cognition and behavior. Brain function and psychological assessment are essential for the early detection of potential impairments, allowing timely interventions to prevent complications and ensure patient safety. This study aims to comprehensively evaluate the physical and psychological impacts of cell therapy on AIHA patients to develop safer and more effective treatment strategies that enhance their quality of life.

Conditions

• CAR T-cell Therapy
• Autoimmune Hemolytic Anemia
• Brain Function
• Psychological Well-Being

Interventions

Type	Name	Description
OTHER	Brain function and psychological assessment	Patients will be assessed before cell therapy and on Days 1, 4, 7, 10, 14, 21, and 28 after treatment.

Timeline

• Start date: 2025-02-25
• Primary completion: 2026-12-31
• Completion: 2026-12-31
• First posted: 2025-04-10
• Last updated: 2025-08-05

Locations

1 site across 1 country: China