NCT06920888

Is Less More? Dosing and Sequencing Effect

Is Less More? Dosing and Sequencing Effects of Cognitive Therapies for Anxiety and Depression

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 180 (estimated)
• Sponsor: University of Aarhus · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

The investigators want to evaluate core components from cognitive behavioral psychotherapies (CBTs) with the aim of investigating dosing and combinatory effects on conditions of anxiety and depression.

Detailed description

In the present study, participants will be randomly assigned to one of four groups, receiving one or both treatment components under investigation, all over the course of six sessions of treatment. 1. It is hypothesized that both component A (Cognitive Restructuring) and component B (External Attention Allocation) will be efficient in reducing symptoms of depression and anxiety when delivered separately, both when delivered over 3 and 6 sessions. The difference between components as well as between the number of sessions on primary and secondary outcomes will be explored. 2. The combinatory effects, comparing the effect of receiving Component A subsequent to Component B and vice versa will be explored. 3. The process of change in both components will be explored. 4. Group differences in participants' experience of being the recipient of the components (either individually or combination) both qualitatively (free descriptions of their experience with using them) and quantitatively (questionnaires concerning the understanding and employment) will be explored. 5. The moderating effect of baseline characteristics including baseline symptomatology, diagnoses, personality functioning, and working alliance will be explored. 6. Potential harmful effects will be explored in each group.

Conditions

• Depression/Anxiety

Interventions

Type	Name	Description
BEHAVIORAL	Cognitive restructuring	CR drawn from classic CBT
BEHAVIORAL	Attention allocation	AA drawn from contemporary CBTs

Timeline

• Start date: 2025-04-01
• Primary completion: 2027-06-30
• Completion: 2027-12-31
• First posted: 2025-04-10
• Last updated: 2025-04-10