NCT06915194

SMART Pilot Trial of Glycemic Screening Outreach

• Status: Enrolling By Invitation
• Phase: N/A
• Study type: Interventional
• Enrollment: 105 (estimated)
• Sponsor: University of California, Los Angeles · Academic / Other
• Sex: All
• Age: 35 Years – 70 Years
• Healthy volunteers: Not accepted

Summary

Approximately 130 million Americans have prediabetes or type 2 diabetes (T2D) but remain unscreened and/or unaware of their diagnosis. While prediabetes/T2D screening, also known as glycemic screening, is endorsed in national guidelines, there is almost no research on how to increase screening rates, or evaluations of interventions testing the effectiveness of screening promotion strategies. The American Medical Association has published prediabetes quality measures that apply to UCLA Health as well as all other health systems, specifically tracking the percentage of adult patients with risk factors for T2D due for glycemic screening for whom the screening process was initiated. However, there is no current systemic effort underway at UCLA, or most other health systems, to encourage glycemic screening. We are proposing a pilot trial of the first SMART (Sequential Multiple Assignment Randomized Trial) for glycemic screening. Our SMART experiment will provide preliminary feasibility and acceptability data for a larger, multisite trial that will provide vital guidance to optimize screening approaches for a growing number of screening-eligible patients so that they may seek earlier detection, treatment, and/or access to lifestyle programs and interventions for T2D or prediabetes.

Conditions

• Overweight (BMI > 25)
• Obesity

Interventions

Type	Name	Description
BEHAVIORAL	Text message	Participants receive a text message encouraging glycemic screening
BEHAVIORAL	Patient portal message	Participants receive a patient portal message encouraging glycemic screening
BEHAVIORAL	Mailed letter	Participants receive a mailed letter encouraging glycemic screening

Timeline

• Start date: 2025-07-08
• Primary completion: 2025-10-08
• Completion: 2025-11-08
• First posted: 2025-04-08
• Last updated: 2025-07-17

Locations

1 site across 1 country: United States