NCT06914401

Oxygenation Procedure for Obese Patients During Intubation in the Operating Room

Oxygenation Procedure for Obese Patients Using High Flow Oxygen Therapy Combined With Non-invasive Ventilation During Intubation in the Operating Room: a Randomised Controlled Trial

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 124 (estimated)
• Sponsor: Clinique Pasteur · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Obesity is a risk factor for difficult intubation, with an incidence of up to 15.5%, and difficult mask ventilation. Obesity also reduces the functional residual capacity (FRC) of the lungs, the main reservoir of oxygen during apnoea. Complications associated with induction and intubation in the operating room are more frequent in obese patients. Preoxygenation is a cornerstone in the management of patients at risk of desaturation during induction. The study aims to compare two oxygenation strategies , in obese patients. Oxygenation using a combination of NIV (Non Invasive Ventilation) and HFNO (High Flow Nasal Oxygen) compared with NIV alone in the operating room for induction of general anaesthesia with orotracheal intubation.

Conditions

• Anesthesia Induction

Interventions

Type	Name	Description
PROCEDURE	NIV (Non Invasive Ventilation) and HFNO (High Flow Nasal Oxygen)	Combination of two procedures Preoxygenation prior to intubation with NIV (Non Invasive Ventilation) and HFNO (High Flow Nasal Oxygen). During intubation, NIV is stopped and apneic oxygenation is maintained with HFNO
PROCEDURE	NIV (Non Invasive Ventilation)	Single procedure Preoxygenation prior to intubation with NIV (Non Invasive Ventilation).

Timeline

• Start date: 2025-06-19
• Primary completion: 2027-03-01
• Completion: 2027-03-01
• First posted: 2025-04-06
• Last updated: 2026-03-06

Locations

5 sites across 1 country: France