NCT06913985

Trajectory Study: Predicting Cardiometabolic Health in Adolescents and Young Adults Based on Childhood Fitness, Sleep, and Diet

• Status: Enrolling By Invitation
• Phase: —
• Study type: Observational
• Enrollment: 250 (estimated)
• Sponsor: Arkansas Children's Hospital Research Institute · Academic / Other
• Sex: All
• Age: 13 Years – 21 Years
• Healthy volunteers: Not accepted

Summary

The Trajectory study aims to determine whether childhood aerobic fitness, sleep quality, and diet quality predict cardiometabolic health during puberty and early adulthood, independently of adiposity.

Detailed description

The Trajectory study is a longitudinal observational study. Participants will be recalled from two existing pediatric cohorts: the Arkansas Active Kids study (ClinicalTrials.gov ID: NCT03221673; IRB #206217) and the MI Energy study (ClinicalTrials.gov ID: NCT04427462; IRB #260376). Both were cross-sectional studies with comparable designs, recruiting children between ages 7 and 10 years, regardless of sex, BMI, or ethnicity. The Trajectory study serves as the follow-up component during adolescence or early adulthood (ages 13-21). It is anticipated that approximately 250 participants will complete the follow-up visit. During the follow-up visit at the Arkansas Children's Nutrition Center (ACNC), the following key measurements will be conducted: * Body Composition: Dual-Energy X-ray Absorptiometry (DXA) * Metabolic Profile: Fasting blood markers, including glucose, lipid profile, and insulin resistance * Continuous Glucose Monitoring: Interstitial sensor-based glucose * Vascular Function: Ultrasound (brachial artery flow-mediated dilation) * Liver Examination: Ultrasound (liver steatosis and stiffness) * Resting Metabolic Rate: Indirect calorimetry * Aerobic Capacity: Cardiopulmonary exercise test (spirometry) * Muscle Strength: Dynamometry * Physical Activity \& Sleep: Accelerometry * Dietary Intake: Food frequency questionary

Conditions

• Cardiometabolic Health

Timeline

• Start date: 2025-05-20
• Primary completion: 2029-12-31
• Completion: 2029-12-31
• First posted: 2025-04-06
• Last updated: 2025-07-02

Locations

2 sites across 1 country: United States