NCT06913790

Evaluation of Central Corneal Thickness in Patients With Vernal Keratoconjunctivitis Using Topical Steroids

• Status: Active Not Recruiting
• Phase: —
• Study type: Observational
• Enrollment: 34 (actual)
• Sponsor: Superior University · Academic / Other
• Sex: All
• Age: 5 Years – 25 Years
• Healthy volunteers: Not accepted

Summary

This prospective observational cohort study aims to assess changes in central corneal thickness (CCT) in vernal keratoconjunctivitis (VKC) patients using topical steroids. Data will be collected from tertiary care hospitals such as Al-Mustafa eye hospital and Jinnah Hospital, Lahore.

Detailed description

A total of 34 participants, including an adjustment for a 10% dropout rate, will be recruited using purposive sampling. The study will last six months. Eligible participants (aged 5-25 years) must have a confirmed VKC diagnosis and be on topical steroids, with exclusions for prior ocular surgery, systemic steroid use, and contact lens wear. Baseline assessments will include demographic data, VKC severity, and CCT measurements via pachymetry and optical coherence tomography. Follow-up evaluations at one and three months will track CCT changes. A paired t-test will compare baseline and follow-up measurements. This study will help understand the impact of topical steroids on CCT in VKC patients.

Conditions

• Vernal Keratoconjunctivitis

Timeline

• Start date: 2025-03-20
• Primary completion: 2025-06-20
• Completion: 2026-02-20
• First posted: 2025-04-06
• Last updated: 2025-04-06

Locations

1 site across 1 country: Pakistan