NCT06911177

Yeast Mannans and Stool Frequency

Efficacy of Yeast Mannan Supplementation on Increasing Stool Frequency in Generally Healthy Adults: A Randomized Controlled Trial

• Status: Active Not Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 70 (estimated)
• Sponsor: University of Florida · Academic / Other
• Sex: All
• Age: 18 Years – 90 Years
• Healthy volunteers: Accepted

Summary

Findings from an open-label pilot study of 20 adults suggested that supplementation with 15 g/day of yeast mannans was highly tolerable and demonstrated specific modulation of the microbiota and increased stool frequency in a subset of subjects reporting ≤1 stool per day at baseline. The primary aim of this randomized, double-blind, controlled trial is to determine if yeast mannan supplementation at 12 g/day will increase stool frequency in generally healthy adults reporting ≤1 stool per day. Secondary aims will determine the effect of yeast mannans on intestinal transit time, gastrointestinal symptoms, fecal microbiota composition, and urinary and fecal metabolomics.

Conditions

• Defecation Frequency

Interventions

Type	Name	Description
DIETARY_SUPPLEMENT	Yeast mannan	Yeast cell wall fraction of manno-oligosaccharides and mannoproteins supplemented at 12 g/day.
DIETARY_SUPPLEMENT	Control (placebo)	A supplement containing yeast protein, yeast extract, and maltodextrin, provided at 12 g/day.

Timeline

• Start date: 2025-07-17
• Primary completion: 2026-03-16
• Completion: 2026-12-31
• First posted: 2025-04-04
• Last updated: 2026-04-15

Locations

1 site across 1 country: United States