NCT06910449

Hemithoracic Arc Radiotherapy Post Pleural Decortication

Hemithoracic Volumetric Modulated Arc Radiotherapy as Part of Lung-Sparing Multimodality Therapy in Patients With Malignant Pleural Mesothelioma Phase II Trial

• Status: Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 45 (estimated)
• Sponsor: Cairo University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Not accepted

Summary

Malignant Pleural Mesothelioma is an aggressive and refractory disease , the most aggressive treatment plan offered to these patients include trimodalitiy approach with chemotherapy as the mainstay of treatment . the rationale of post operative Radiotherapy is to sterilize the post operative volume to reduce local failure meanwhile minimizing toxicities in this trial we are going to assess the safety and efficacy of Radiotherapy in Mesothelioma patients poat Pleural decortication

Detailed description

This study will include malignant Pleural Mesothelioma patients treated by trimodalitiy approach starting with neoadjuvant chemotherapy followed by surgery in the form of Pleural decortication then all patients will receive post operative hemithoracic radiation

Conditions

• Malignant Pleural Mesothelioma

Interventions

Type	Name	Description
RADIATION	hemithoracic Volumetric Arc Radiotherapy post Pleural decortication	post operative delivery of hemithoracic Volumetric Arc Radiotherapy

Timeline

• Start date: 2024-11-11
• Primary completion: 2026-11-01
• Completion: 2027-02-01
• First posted: 2025-04-04
• Last updated: 2025-04-08

Locations

1 site across 1 country: Egypt