NCT06910241

Lidocaine Versus Diphenhydramine to Achieve Local Anesthesia for Laceration Repairs

• Status: Recruiting
• Phase: Phase 3
• Study type: Interventional
• Enrollment: 100 (estimated)
• Sponsor: Florida Atlantic University · Academic / Other
• Sex: All
• Age: 18 Years
• Healthy volunteers: Accepted

Summary

Diphenhydramine, when injected locally, has been shown to achieve a certain level of local anesthesia. It has been documented for use in simple bedside procedures, however there is a gap in knowledge in its comparison to lidocaine. The purpose of the study is to determine if local infiltration of diphenhydramine is noninferior to the use of lidocaine 1% when trying to achieve local anesthesia for simple laceration repair. Patients who present to the emergency department with a simple laceration will be enrolled in the study. Patients will be evaluated for the pain of the injection as well as the pain of the laceration repair procedure post injection.

Conditions

• Laceration of Skin

Interventions

Type	Name	Description
DRUG	Lidocaine	Lidocaine local infiltration
DRUG	Diphenhydramine	Diphenhydramine local infiltration

Timeline

• Start date: 2025-09-03
• Primary completion: 2027-06-30
• Completion: 2028-06-30
• First posted: 2025-04-04
• Last updated: 2026-01-07

Locations

1 site across 1 country: United States

Regulatory

• FDA-regulated drug study