NCT06907823

Comparison of Sevoflurane and Propofol on ANI

Comparison of Sevoflurane and Propofol on ANI in Patients Undergoing General Anesthesia: a Prospective Randomized Controlled Study

• Status: Not Yet Recruiting
• Phase: N/A
• Study type: Interventional
• Enrollment: 30 (estimated)
• Sponsor: Pusan National University Yangsan Hospital · Academic / Other
• Sex: All
• Age: 19 Years
• Healthy volunteers: Not accepted

Summary

The goal of this clinical trial is to compare the effect of sevoflurane and propofol on analgesia nociception index(ANI) in patients undergoing general anesthesia. The main question it aims to answer is whether propofol anesthesia results in lesser ANI change to a nociceptive stimulation compared to sevoflurane.

Detailed description

Patients will be allocated to either propofol or sevoflurane group. Nociceptive event will be defined as long-lasting tetanic stimulation, square-wave, duration of 30 seconds , amplitude of 50mA, frequency of 50 Hz. analgesia nociception index value and hemodynamic parameters will be recorded 1-minute before and after nociceptive event.

Conditions

• Propofol
• Sevoflurane
• Analgesia Nociception Index

Interventions

Type	Name	Description
DRUG	propofol	propofol anesthesia
DRUG	Sevoflurane	sevoflurane anesthesia

Timeline

• Start date: 2025-06-30
• Primary completion: 2025-12-31
• Completion: 2025-12-31
• First posted: 2025-04-02
• Last updated: 2025-06-10