NCT06907693

The Effects of Drug Candidate CS1 on Lung Structure and Function Utilizing FRI

The Effects of Drug Candidate CS1 on Lung Structure and Function Utilizing FRI, a Non-Invasive, Functional Respiratory Imaging System

• Status: Completed
• Phase: —
• Study type: Observational
• Enrollment: 7 (actual)
• Sponsor: Prisma Health-Upstate · Academic / Other
• Sex: All
• Age: —
• Healthy volunteers: Not accepted

Summary

Explore the impact of drug candidate CS1 on pathological vascular remodeling of small pulmonary arteries in the disease pulmonary arterial hypertension (PAH). This sub-study for CS1-004 aims to utilize FRI, an innovative, non-invasive imaging technology to visualize how long-term use of CS1 influences structural changes in pulmonary arteries. This sub-study seeks to provide valuable insights into the potential of CS1 to transform PAH treatment in some patients enrolled in the Expanded Access Program (CS1-004).

Conditions

• Pulmonary Arterial Hypertension

Interventions

Type	Name	Description
DIAGNOSTIC_TEST	CT Pulmonary Angiography Scan	Computed tomography (CT) pulmonary angiography scan of the chest with IV contrast

Timeline

• Start date: 2025-03-14
• Primary completion: 2025-12-04
• Completion: 2026-04-09
• First posted: 2025-04-02
• Last updated: 2026-04-13

Locations

1 site across 1 country: United States